SPECT Imaging With DaTscan

How it can help with a parkinsonian syndrome diagnosis

Your doctor has prescribed a DaTscan imaging test for you or someone for whom you care. This test will give your doctor information to help him or her understand the symptoms that you or your loved one is experiencing.

Dopamine deficiency may affect many of your or your loved one’s
brain functions. There is a test that can help show whether there is a loss of
dopamine transporters in the brain. Along with other clinical tests, this imaging test can help your doctor determine whether the symptoms are the result of a parkinsonian syndrome (PS) or essential tremor (ET).

DaTscan is an imaging drug that will be injected into the bloodstream to help your doctor assess dopamine transporters, which help recycle dopamine, a chemical involved in controlling movement. A special device, called a gamma camera, will take pictures of the brain (called a single-photon emission computed tomography [SPECT] scan). These pictures and a report will be sent to your doctor, who can discuss the test results with you or your loved one.

Although DaTscan does not diagnose a PS or ET, the findings of SPECT imaging with DaTscan may be used, in addition to other clinical tests, to help make a diagnosis.

PSs occur when the brain is not getting enough of the dopamine it needs to perform certain functions. This affects the ability of the brain to control movement and other muscle functions.

There are different types of PSs. The most common is Parkinson’s disease, also known as PD. Other types include multiple system atrophy and progressive supranuclear palsy. DaTscan cannot distinguish between these different syndromes. In combination with other tests and the clinical assessment
of your particular symptoms, DaTscan may help your doctor determine if you are suffering from a
parkinsonian syndrome.

Imaging with DaTscan will be performed in the Nuclear Medicine department of a hospital or in an
outpatient clinic.

DaTscan is for adult patients who have signs or symptoms of parkinsonian syndromes, such as shaking or stiffness. DaTscan is available only with a prescription from your doctor, and only your doctor can decide if this test is right for you.

This test is NOT for:

  • Patients with a known allergy or sensitivity to iodine
  • Patients with a known sensitivity to DaTscan
  • Children

This test may not be right for:

  • Patients who are pregnant
  • Patients who are nursing
  • Patients with reduced kidney or liver function

Sensitivity reactions (such as rash or itching) have been reported after administration of DaTscan. In clinical trials, the most common side effects were headache, nausea, dry mouth, or dizziness.

If you have any questions, please talk with your doctor. For additional information, please see the Full Prescribing Information for DaTscan.

What is Datscan (Ioflupane I 123 Injection)?

DaTscan is a radioactive drug that is injected into your bloodstream to highlight areas of your brain so that images can be taken with a special camera (called a single-photon emission computed tomography [SPECT] camera). If you are an adult with a movement difficulty, your doctor may decide to order this imaging test, along with other medical tests, to help decide if your movement difficulties are due to a parkinsonian syndrome or a similar condition such as essential tremor.

Types of parkinsonian syndromes are Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy. DaTscan cannot tell the difference between these parkinsonian syndromes.

DaTscan is available only by prescription and must be ordered by your doctor.

Important Risk and Safety Information About DaTscan

You should not be given DaTscan if:
  • You have ever had a reaction to iodine or are sensitive to any of the components of DaTscan. Talk with your doctor; he or she can help you understand what the drug ingredients are
What is the most important information you should know about DaTscan?
  • Serious allergic and injection-site reactions could occur following a DaTscan injection. If you have any symptoms of a serious allergic nature, including low blood pressure; trouble breathing; throat tightness; swelling of your face, lips, or tongue; or rash and itching, inform your doctor or go to your nearest emergency room right away
  • To help decrease the amount of thyroid accumulation of iodine: Your doctor will give you a medication at least one hour before giving you DaTscan. The purpose of this medication is to minimize the amount of radioactive iodine going into your thyroid gland
  • Pregnancy: Clinical studies have not been conducted with DaTscan on pregnant women. Any radioactive drug, including DaTscan, may cause harm to the fetus. If you are pregnant, your doctor will decide if a DaTscan test is appropriate
  • If your are a nursing mother, your doctor will decide whether you should interrupt nursing and pump and discard breast milk for six days after DaTscan administration to reduce the risks to your nursing infant
  • If you have kidney and/or liver problems: The effects of kidney and /or liver damage from the use of DaTscan are not certain. DaTscan is removed by the kidney, and patients with severe kidney problems may have increased radiation exposure that could change DaTscan images
  • Children: DaTscan should not be given to children
The most common side effects of DaTscan:
  • In clinical studies performed, the most common side effects included headache, nausea and upset stomach, a sensation of motion, dry mouth, or dizziness in less than 1% of patients (1 in 100 patients)
What you should know about taking DaTscan with other medications:
    Some drugs may interfere with DaTscan. Be sure to tell your doctor what drugs you are taking so that he or she can decide whether you should stop any of them for a period of time before using DaTscan
Questions about the procedure:
    Always talk to your doctor if you have any questions about the SPECT imaging procedure or the use of DaTscan
Your doctor should advise you to:
    Increase your level of hydration (fluids) prior to and after receiving DaTscan, and to empty your bladder frequently for the first 48 hours following DaTscan administration

The safety information included here is not comprehensive. If you have any questions, please be sure to discuss them with your doctor.

For more information about DaTscan, call GE Healthcare at 800 654 0118.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 800 FDA 1088.

For more information about DaTscan, call GE Healthcare at 1-800-654-0118.

Please see the Full Prescribing Information for DaTscan at www.Datscan.com.