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Dosing Image Acquisition

Camera-Specific Parameters

Selecting camera settings for optimal image quality

Each single-photon emission computed tomography (SPECT) camera requires its own specific setup parameters for acquiring DaTscan images.

GE Discovery 670/630 Dual Head
  • Radius of rotation ~13 cm
  • Collimation – LEHR (must select “scan on extender” and use the head holder)
  • Energy window – 159 keV, 20%
  • Projection angles – 120 (60 on each head) over 360°
  • Image matrix – 128 x 128, zoom 1.25 (~3.53 mm)
  • Time per projection – 30 sec
  • FBP, 2-D Butterworth pre-filter, power factor 10, cutoff 0.6
  • Total counts ~1.8 million

GE Discovery

Recommended camera-acquisition parameters:

  • Double- or triple-headed SPECT gamma camera system
  • Low-energy, high-resolution collimators, or ultra-high-resolution fanbeam collimators
  • Supine positioning with head off the imaging table in a suitable headrest, with restraint to minimize radius of rotation and
    prevent motion
  • Circular 360° orbit
  • Radius of rotation as close as possible, 11-15 cm; 13-cm radius
    is ideal
  • Double-head camera – 30 sec/frame
  • Triple-head camera – 45 sec/frame
  • Minimum imaging time – 30 minutes
  • Matrix size 128 x 128
  • 159 KeV ±10% energy window (20% total window width)
  • Minimum of 1.5 million counts required for optimal image quality
  • Always image with DaTscan using the same camera parameters

Close

GE Millennium VG/Elscint Varicam
  • Radius of rotation <14 cm
  • Collimation – LEHR, parallel
  • Energy window – 159 keV, 20%
  • Projection angles – 120 over 360º
  • Image matrix – 128 x 128, zoom 1.2 (3.7 mm)
  • Time per projection – 30 sec
  • Filter depends on system: IGE Butterworth factor 8-10: cutoff 0.32
Phantom Image

Phantom Image

Normal Image

Normal Image

Abnormal Image

Abnormal Image

Recommended camera-acquisition parameters:

  • Double- or triple-headed SPECT gamma camera system
  • Low-energy, high-resolution collimators, or ultra-high-resolution fanbeam collimators
  • Supine positioning with head off the imaging table in a suitable headrest, with restraint to minimize radius of rotation and
    prevent motion
  • Circular 360º orbit
  • Radius of rotation as close as possible, 11-15 cm; 13-cm radius
    is ideal
  • Double head camera 30 sec/frame
  • Triple head camera 45 sec/frame
  • Minimum imaging time – 30 minutes
  • Matrix size 128 x 128
  • 159 keV ±10% energy window (20% total window width)
  • A minimum of 1.5 million total counts is required for optimal
    image quality
  • Always image with DaTscan using the same camera parameters

Close

GE Infinia
  • Radius of rotation – 13 cm
  • Collimation – LEHR
  • Energy window – 159 keV, 20%
  • Projection angles – 120 over 360º
  • Image matrix – 128 x 128, zoom 1.2 (~3.7 mm)
  • Time per projection – 30 sec
  • FBP, 2-D Butterworth pre-filter, power factor 10, cutoff 0.6
Phantom Image

Phantom Image

Normal Image

Normal Image

Abnormal Image

Abnormal Image

Recommended camera-acquisition parameters:

  • Double- or triple-headed SPECT gamma camera system
  • Low-energy, high-resolution collimators, or ultra-high-resolution fanbeam collimators
  • Supine positioning with head off the imaging table in a suitable headrest, with restraint to minimize radius of rotation and
    prevent motion
  • Circular 360º orbit
  • Radius of rotation as close as possible, 11-15 cm; 13-cm radius
    is ideal
  • Double head camera 30 sec/frame
  • Triple head camera 45 sec/frame
  • Minimum imaging time – 30 minutes
  • Matrix size 128 x 128
  • 159 keV ±10% energy window (20% total window width)
  • A minimum of 1.5 million total counts is required for optimal
    image quality
  • Always image with DaTscan using the same camera parameters

Close

ADAC Forte
  • Radius of rotation
  • Collimation – Parallel VXGP/VXHR
  • Energy window – 159 keV, 20%
  • Projection angles –120 over 360º
  • Image matrix – 128 x 128, no zoom (~4.6 mm)
  • Time per projection – 30 sec
  • FBP Butterworth cutoff 0.6, order 8
Phantom Image

Phantom Image

Normal Image

Normal Image

Abnormal Image

Abnormal Image

Recommended camera-acquisition parameters:

  • Low-energy, high-resolution collimators, or ultra-high-resolution fanbeam collimators
  • Supine positioning with head off the imaging table in a suitable headrest, with restraint to minimize radius of rotation and
    prevent motion
  • Circular 360º orbit
  • Radius of rotation as close as possible, 11-15 cm; 13-cm radius
    is ideal
  • Double head camera 30 sec/frame
  • Triple head camera 45 sec/frame
  • Minimum imaging time – 30 minutes
  • Matrix size 128 x 128
  • 159 keV ±10% energy window (20% total window width)
  • A minimum of 1.5 million total counts is required for optimal
    image quality
  • Always image with DaTscan using the same camera parameters

Close

Philips Prism 2000
  • Radius of rotation – 14 cm
  • Collimation – UHR
  • Energy window – 159 keV, 20%
  • Projection angles – 120 over 360º
  • Image matrix – 128 x 128, zoom 1.33 (~3.5 mm)
  • Time per projection – 30 sec
  • FBP, 3-D lowpass post-filter; 0.6 cycles/pixel, power factor 8

philips-prism-phantom
philips-prism-normal
philips-prism-abnormal

Recommended camera-acquisition parameters:

  • Double- or triple-headed SPECT gamma camera system
  • Low-energy, high-resolution collimators, or ultra-high-resolution fanbeam collimators
  • Supine positioning with head off the imaging table in a suitable headrest, with restraint to minimize radius of rotation and
    prevent motion
  • Circular 360º orbit
  • Radius of rotation as close as possible, 11-15 cm; 13-cm radius
    is ideal
  • Double head camera 30 sec/frame
  • Triple head camera 45 sec/frame
  • Minimum imaging time – 30 minutes
  • Matrix size 128 x 128
  • 159 keV ±10% energy window (20% total window width)
  • A minimum of 1.5 million total counts is required for optimal
    image quality
  • Always image with DaTscan using the same camera parameters

Close

Philips Axis
  • Radius of rotation – 13 cm
  • Collimation – Parallel, HR (1) or fanbeam (2)
  • Energy window – 159 keV, 20%
  • Projection angles – 120 over 360º
  • Image matrix – 128 x 128, zoom 1.33 (~3.5 mm)
  • Time per projection – 30 sec
  • Full-back projection
  • 3-D lowpass post-filter; 0.5 cycles/pixel, power factor 8

philips-prism-phantom (1)
philips-prism-normal (1)
philips-prism-abnormal (1)

Recommended camera-acquisition parameters:

  • Double- or triple-headed SPECT gamma camera system
  • Low-energy, high-resolution collimators, or ultra-high-resolution fanbeam collimators
  • Supine positioning with head off the imaging table in a suitable headrest, with restraint to minimize radius of rotation and
    prevent motion
  • Circular 360º orbit
  • Radius of rotation as close as possible, 11-15 cm; 13-cm radius
    is ideal
  • Double head camera 30 sec/frame
  • Triple head camera 45 sec/frame
  • Minimum imaging time – 30 minutes
  • Matrix size 128 x 128
  • 159 keV ±10% energy window (20% total window width)
  • A minimum of 1.5 million total counts is required for optimal
    image quality
  • Always image with DaTscan using the same camera parameters

Close

SMV Dual Head
  • Radius of rotation – 12.5-13.5 cm
  • Collimation – LEHR, parallel hole
  • Energy window – 159 keV, 20%
  • Projection angles – 128 over 360º
  • Image matrix – 128 x 128 (~3.8 mm), zoom 1.12 or 1.33 (~3.3 mm)
  • Time per projection – 30 sec
  • FBP, 2-D pre-filter, Butterworth 8-10, 0.5
Phantom Image

Phantom Image

Normal Image

Normal Image

Abnormal Image

Abnormal Image

Recommended camera-acquisition parameters:

  • Double- or triple-headed SPECT gamma camera system
  • Low-energy, high-resolution collimators, or ultra-high-resolution fanbeam collimators
  • Supine positioning with head off the imaging table in a suitable headrest, with restraint to minimize radius of rotation and
    prevent motion
  • Circular 360º orbit
  • Radius of rotation as close as possible, 11-15 cm; 13-cm radius
    is ideal
  • Double head camera 30 sec/frame
  • Triple head camera 45 sec/frame
  • Minimum imaging time – 30 minutes
  • Matrix size 128 x 128
  • 159 keV ±10% energy window (20% total window width)
  • A minimum of 1.5 million total counts is required for optimal
    image quality
  • Always image with DaTscan using the same camera parameters

Close

Siemens ECAM Dual Head
  • Radius of rotation – 13 cm
  • Collimation – LEHR
  • Energy window – 159 keV, 15%
  • Projection angles – 120 over 360º
  • Image matrix – 128 x 128, zoom 1.23 (~3.89 mm)
  • Time per projection – 30 sec
  • FBP, 2-D Butterworth pre-filter, power factor 8, cutoff 0.6
Phantom Image

Phantom Image

Normal Image

Normal Image

Abnormal Image

Abnormal Image

Recommended camera-acquisition parameters:

  • Double- or triple-headed SPECT gamma camera system
  • Low-energy, high-resolution collimators, or ultra-high-resolution fanbeam collimators
  • Supine positioning with head off the imaging table in a suitable headrest, with restraint to minimize radius of rotation and
    prevent motion
  • Circular 360º orbit
  • Radius of rotation as close as possible, 11-15 cm; 13-cm radius
    is ideal
  • Double head camera 30 sec/frame
  • Triple head camera 45 sec/frame
  • Minimum imaging time – 30 minutes
  • Matrix size 128 x 128
  • 159 keV ±10% energy window (20% total window width)
  • A minimum of 1.5 million total counts is required for optimal
    image quality
  • Always image with DaTscan using the same camera parameters

Close

Siemens Symbia Dual Head
  • Radius of rotation – 13.0 cm (14-cm CT headrest)
  • Collimation – LEHR
  • Energy window – 159 keV, 15%
  • Projection angles – 120 over 360°
  • Image matrix – 128×128, zoom 1.23 (~3.89 mm)
  • Time per projection – 30 sec
  • FBP, 2-D Butterworth prefilter, power factor 8, cutoff 0.6
datscan_siemens_symbia_dual_head_normal

Phantom Image

datscan_siemens_symbia_dual_head_normal

Normal Image

datscan_siemens_symbia_dual_head_abnormal

Abnormal Image

Recommended camera-acquisition parameters:

  • Double- or triple-headed SPECT gamma camera system
  • Low-energy, high-resolution collimators, or ultra-high-resolution fanbeam collimators
  • Supine positioning with head off the imaging table in a suitable headrest, with restraint to minimize radius of rotation and
    prevent motion
  • Circular 360º orbit
  • Radius of rotation as close as possible, 11-15 cm; 13-cm radius
    is ideal
  • Double head camera 30 sec/frame
  • Triple head camera 45 sec/frame
  • Minimum imaging time – 30 minutes
  • Matrix size 128 x 128
  • 159 keV ±10% energy window (20% total window width)
  • A minimum of 1.5 million total counts is required for optimal
    image quality
  • Always image with DaTscan using the same camera parameters

Close

I don’t see my camera

If your camera is not listed above, please contact your GE Healthcare Sales Specialist for additional information.

Recommended camera-acquisition parameters:

  • Double- or triple-headed SPECT gamma camera system
  • Low-energy, high-resolution collimators, or ultra-high-resolution fanbeam collimators
  • Supine positioning with head off the imaging table in a suitable headrest, with restraint to minimize radius of rotation and
    prevent motion
  • Circular 360º orbit
  • Radius of rotation as close as possible, 11-15 cm; 13-cm radius
    is ideal
  • Double head camera 30 sec/frame
  • Triple head camera 45 sec/frame
  • Minimum imaging time – 30 minutes
  • Matrix size 128 x 128
  • 159 keV ±10% energy window (20% total window width)
  • A minimum of 1.5 million total counts is required for optimal
    image quality
  • Always image with DaTscan using the same camera parameters

Close

Potential obstacles to obtaining good images

Patient movement

  • Always check raw data immediately after acquiring the study

Image reorientation

  • Lateral head tilt can cause difficulties

image-reorientation

A headrest is always required for SPECT imaging with DaTscan. Using a headrest helps enable consistent positioning of the patient and minimizes the camera’s radius of rotation. It is recommended that a flexible headrest be used.

PRODUCT INDICATIONS AND USE: DaTscan (Ioflupane I 123 Injection) is a radiopharmaceutical indicated for striatal dopamine transporter visualization using single-photon emission computed tomography (SPECT) brain imaging to assist in the evaluation of adult patients with suspected parkinsonian syndromes (PSs). DaTscan may be used to help differentiate essential tremor from tremor due to PS (idiopathic Parkinson’s disease [PD], multiple system atrophy [MSA], and progressive supranuclear palsy [PSP]). DaTscan is an adjunct to other diagnostic evaluations. DaTscan was not designed to distinguish among PD, MSA, and PSP. The effectiveness of DaTscan as a screening or confirmatory test and for monitoring disease progression or response to therapy has not been established.

Important Risk and Safety Information About DaTscan

CONTRAINDICATIONS: DaTscan is contraindicated in patients with known hypersensitivity to the active substance, any of the excipients, or iodine. WARNINGS AND PRECAUTIONS — Hypersensitivity Reactions: Hypersensitivity reactions, generally consisting of skin erythema and pruritus, have been reported following DaTscan administration. Thyroid Accumulation: The DaTscan injection may contain up to 6% of free iodide (iodine 123 or I-123). To decrease thyroid accumulation of I-123, block the thyroid gland at least one hour before administration of DaTscan; failure to do so may increase the long-term risk for thyroid neoplasia. ADVERSE REACTIONS: In clinical trials, headache, nausea, vertigo, dry mouth, or dizziness of mild to moderate severity were reported. In postmarketing experience, hypersensitivity reactions and injection-site pain have been reported. DRUG INTERACTIONS: Drugs that bind to the dopamine transporter with high affinity may interfere with the DaTscan image. The impact of dopamine agonists and antagonists on DaTscan imaging results has not been established. SPECIFIC POPULATIONS — Pregnancy: It is unknown whether DaTscan can cause fetal harm or increase the risk of pregnancy loss in pregnant women. DaTscan should be given to pregnant women only if clearly needed. Like all radiopharmaceuticals, DaTscan may cause fetal harm, depending on the stage of fetal development and the magnitude of the radionuclide dose. Radioactive iodine products cross the placenta and can permanently impair fetal thyroid function. Nursing Mothers: It is not known whether DaTscan is excreted into human milk; however, I-123 is excreted into human milk. Because many drugs are excreted into human milk and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to interrupt nursing after administration of DaTscan or not to administer DaTscan at all. Nursing women may consider interrupting nursing and pumping and discarding breast milk for six days after DaTscan administration to minimize risks to a nursing infant. Pediatric Use: The safety and efficacy of DaTscan have not been established in pediatric patients. Geriatric Use: There were no differences in responses between the elderly and younger patients that would require a dose adjustment. Renal and Hepatic Impairment: The effect of renal or hepatic impairment on DaTscan imaging has not been established. The kidney excretes DaTscan; patients with severe renal impairment may have increased radiation exposure and altered DaTscan images. OVERDOSAGE: It is unknown whether or not ioflupane is dialyzable. The major risks of overdose relate to increased radiation exposure and long-term risk for neoplasia. In case of radioactivity overdosage, frequent urination and defecation should be encouraged to minimize radiation exposure to the patient. PROCEDURE — Radiation Safety: DaTscan emits radiation and must be handled with safety measures to minimize radiation exposure to clinical personnel and patients.

Prior to DaTscan administration, please read the Full Prescribing Information.